Association of Race and Breast Cancer Stage. RESULTS
Posted by JamesFive-thousand, seven-hundred-fifty-one patients (5,119 Caucasians, 632 African Americans) were eligible to be included in the study. There was no significant difference for menopausal status, topography, morphology and laterality of their breast cancers. African Americans were significantly younger, with a younger onset of menopause, less family history of breast cancer, fewer positive estrogen and progesterone receptors, more cigarette smokers, more Medicaid insured and more single and divorced individuals compared to Caucasians Americans (Table 1, p O.05). Multivariate analysis found no difference between the races for stage 0, stage 2 and stage 4 (Table 2). African Americans had significantly less stage-1 breast cancer (RR 0.80, 95% CI: 0.67-0.96), less combined stage 0 and 1 (RR 0.75, 95% CI: 0.63-0.89) and more combined stage-3 (RR 1.50 95% CI: 1.11-2.01).
Table 1. Univariate analysis—race and breast cancer stage
| Variable Caucasians (N=5,119) |
African Americans (N=632) |
Odds Ratio* P Value | |
| Marital Status |
O.01 |
||
| Single | 463 (9.0%) |
119 (18.8%) |
|
| Married | 3,344 (65.3%) |
280 (44.3%) |
|
| Divorced | 435 (8.5%) |
119 (18.8%) |
|
| Widowed | 877 (17.1%) |
114 (18.0%) |
|
| Smoking |
O.01 |
||
| Nonsmoker | 3,519 (68.7%) |
373 (59.0%) |
|
| Cigarettes | 968 (18.9%) |
180 (28.5%) |
|
| Ex-smoker | 632 (12.3%) |
79 (12.5%) |
|
| Family Hx of Breast Cancer |
0.78 0.02 |
||
| Yes | 1,124 (22.0%) |
114 (18.0) |
|
| No | 3,995 (78.0%) |
518 (82.0%) |
|
| Estrogen Receptors |
0.49 <0.01 |
||
| Yes | 2,831 (78.5%) |
306 (64.3%) |
|
| No | 774 (21.5%) |
170 (35.7%) |
|
| Progesterone Receptors |
0.58 <0.01 |
||
| Yes | 2,363 (65.5%) |
247 (52.3%) |
|
| No | 1,246 (34.5%) |
225 (47.7%) |
|
| Medicaid |
3.33 <0.01 |
||
| Yes | 126 (2.5%) |
49 (7.8%) |
|
| No | 4,993 (97.5%) |
583 (92.2%) |
|
| Age | 58.6 ± 13.5 |
56.4 ± 13.4 |
<0.01 |
| Menopausal Age | 46.0 ± 7.0 |
42.9 ± 7.2 |
<0.01 |
| Topography |
0.12 |
||
| Axillary tail | 13 (0.3%) |
5 (0.8%) |
|
| Breast NOS, overlapping | 2,298 (44.9%) |
288 (45.6%) |
|
| Lower, inner quadrant | 223 (4.4%) |
31 (4.9%) |
|
| Lower, outer quadrant | 303 (5.9%) |
39 (6.2%) |
|
| Nipple | 48 (0.9%) |
1 (0.2%) |
|
| Upper, inner quad | 384 (7.5%) |
43 (6.8%) |
|
| Upper, outer quad | 1,850 (36.1%) |
225 (35.6%) |
|
| Morphology |
0.07 |
||
| Infiltrating ductal | 3,533 (69.0%) |
455 (72.0%) |
|
| Noninfiltrating intraductal | 440 (8.6%) |
36 (5.7%) |
|
| Lobular | 272 (5.3%) |
30 (4.7%) |
|
| Others | 874 (17.1%) |
111 (17.6%) |
|
| Laterality |
0.32 |
||
| Left | 2,631 (51.4%) |
338 (53.5%) |
|
| Right | 2,488 (48.6% |
294 (46.5%) |
|
| Menopausal Status |
0.24 |
||
| Premenopausal | 1171 (22.9%) |
154 (24.4%) |
|
| Perimenopausal | 279 (5.5%) |
32 (5.1%) |
|
| Postmenopausal | 3,455 (67.5%) |
410 (64.9%) |
|
| Unknown | 214 (4.2%) |
36 (5.7%) |
|
| * Odds of an African-American woman being positive compared to a Caucasian women | |||
Table 2. Adjusted multivariate analysis*—race and breast cancer stage
| AJCC Stage | Odds Ratio** | 95% CI | P Value |
| 0 | 0.15 | (0.02-1.12) | 0.06 |
| 1 | 0.80 | (0.67-0.96) | 0.02 |
| 0 and 1 | 0.75 | (0.63-0.89) | 0.001 |
| 2 | 1.16 | (0.98-1.39) | 0.09 |
| 3 | 1.50 | (1.11-2.01) | 0.01 |
| 4 | 0.98 | (0.79-1.21) | 0.85 |
| * Controlling for family history, marital status, smoking, estrogen and progesterone receptors, insurance status, age, menopausal age; | |||
| ** The odds of an African-American women being in each stage compared to a Caucasian women. | |||
Add A Comment