42nd Annual Meeting: High-Risk Cytogenetic Abnormalities Respond to Alemtuzumab in Patients with B-Cell Chronic Lymphocytic Leukemia
Posted by James
High-Risk Cytogenetic Abnormalities Respond to Alemtuzumab in Patients with B-Cell Chronic Lymphocytic Leukemia
Presenter: Anna Dmoszynska, MD, Professor, Department of Hematology, Medical University of Lublin, Lublin, Poland
A cytogenetic profile of the patients participating in a large-scale clinical trial comparing alemtuzumab (Campath, Berlex/ Genzyme) with chlorambucil (Leukeran, GlaxoSmithKline) in previously untreated patients with progressive B-cell chronic lymphocytic leukemia (B-CLL) demonstrated statistically superior overall response rates and complete response rates to alemtuzumab in patients with certain poor prognostic cyto-genetic abnormalities compared with patients treated with chlorambucil. This drug looks promising as a novel, more effective therapeutic option for patients with poor-risk B-CLL.