Stability of Nitrofurantoin in Extemporaneously Compounded Suspensions: DISCUSSION

The lack of a commercially available suspension of nitrofurantoin in Canada poses a problem for children and adults who are unable to swallow tablets and capsules. Until the time of this study, nitrofurantoin suspensions used at the authors’ institution had been extemporaneously prepared in a methylcellulose vehicle. This product had an expiration date of only 8 days when kept refrigerated. To the authors’ knowledge, there are no published stability studies on nitrofurantoin suspensions prepared in a 1:1 mixture of Ora-Sweet and Ora-Plus.

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