Alterations in Serum Creatine Kinase and Lactate Dehydrogenase

Posted by James

Previous experimental work from our laboratory and some clinical reports suggest that peripheral serum С К becomes elevated with acute bowel infarc­tion. The CK-MM is the dominant isoenzyme of the elevation, but CK-MB rises early and stays elevated, particularly in experimental animals with lethal inju­ries. Serum CK-BB also rises early, but decreases within 24 hours of the infarction. Monitoring of serum LD in acute experimental bowel infarction has shown that total serum LD rises only slightly with LD₃ becoming the dominant isoenzyme in some instances. Reports from our institution and other cen­ters suggest that similar changes occur in patients with bowel necrosis. The following prospective study was conducted to test whether the changes in these serum enzyme systems seen in acute bowel infarction could be differentiated from those seen in AMI and from changes which occur in patients who have undergone uncomplicated AAS. Differentiation of these three conditions may be required in a critical care setting wherein the exact diagnosis is unknown and rapid determination of the precise diagnosis may be essential for the survival of the patient. levitra plus