Sodium Disorders in the Elderly: Water Metabolism
Posted by JamesWater Metabolism
Water, comprising 55-65% of healthy adults, is the predominant constituent of the human body. This percentage diminishes proportionally with age, as the ratio of muscle to water-poor tissues, such as fat and bone, falls. Between 55% and 75% of water is contained within the intracellular compartment. Serum constitutes approximately one-fourth of the extracellular space, and antidiuretic hormone (ADH)—a nonapeptide produced by the neurohypophysis—closely regulates the water content within this compartment. Although multiple variables influence the secretion of ADH under normal physiologic conditions, the most important modulator of ADH secretion is the serum osmolality.
Categories: Health
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