Posted by James
The study has shown the efficacy and tolerability of Toto products (skin ointment and soap) in the management of common skin disorders. It also has a superior outcome as compared with sulfur ointment, a commonly used skin product. It is particularly efficacious in the management of skin conditions such as fungal and bacterial skin infections and scabies. The products are particularly effective in treating fungal infections and scabies. Such fungal skin infections include tinea cruris, corporis, pubis, and capitis. In treating tinea unguium and tinea pedis however, although the products have some effects, a definitive statement is difficult to make concerning the efficacy because of the few patients and duration of treatment. We suggest application of the ointment for a longer period in the management of tinea unguium and tinea pedis. Very few cases of dandruff and acne vulgaris were seen to allow for determination of the effects of the products, although the clinical trial recorded good effects on all the cases seen. Toto products were also effective in treating common bacterial skin infections such as folliculitis and septic spots caused especially by Staphylococcus aureus. The clinical trial has shown that there is an added advantage in combining Toto skin ointment and soap over and above those conferred by the individual agents, while treating fungal skin infections.
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Posted by James
A total of 607 patients were seen at the beginning of the study period but 12 (1.8%) could not satisfy the inclusion criteria fully. Five hundred and ninety-five patients participated in the clinical trial, all of which were Nigerians. Their ages ranged from six years to seventy-five years (mean 13.87 ± 10.55 years) with a sex ratio M/F of 1:1, (302 males and 293 females), and a mean body mass index of 17.2 ± 5.5.
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Posted by James
This clinical trial was carried out in the medical outpatient department of the Ogun State University Teaching Hospital (OSUTH), Sagamu. Study participants also were recruited from area schools. Local ethical committee approval was obtained. This is a randomized, comparative, parallel, prospective, and blinded observational study.
- Inclusion criteria: Patient must be Nigerian and have any of the common skin diseases such as acne vulgaris, dandruff, scabies, fungal and bacterial skin infections.
- Exclusion Criteria: Patients with known hy-persensitivity/contraindication to sulfur; renal impairment; clinically significant abnormality of haematopoietic, hepatic, endocrine or cardiac function and existence of any concurrent disease, which in the investigator opinion would make it undesirable for the patient to participate in the study. Others include women of childbearing age who are not using an acceptable method of birth control; breast-feeding mothers; presence of psychosis, antagonist personality or poor motivation, emotional or intellectual property that is likely to impair compliance with trial procedures or validity of consent.
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Posted by James
INTRODUCTION
The traditional practices of topically treating dermatological conditions with plant-derived medicines predate the cultures of ancient Egypt and remain vital today in the industrialized cultures of both the United States and Europe. Recent scientific studies lend support to some of the claims of herbal practitioners for the safety and efficacy of many herbal remedies. Dermatologists are largely unfamiliar with herbal remedies and may harbor some misconceptions.
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Posted by James
RVT is a clotting process that originates in the venous radicles and progresses into the main renal vein and vena cava. In Germany, the minimum incidence of symptomatic neonatal RVT between 1992 and 1994 was 2.2 per 100,000 live births. Zigman et al reported an incidence of 2.3 cases/year in Canada. Review of the literature in PubMed, African Journal online and Embasse showed no reports from Africa and Japan.
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Posted by James
UN is a two-hour-old male admitted into the Special Care Baby Unit (SCBU) of the University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria due to macrosomia, birthweight of 4.6 kg. He was the fourth child of a mother who had one other live child and two miscarriages (para Г mother). He was delivered by normal vertex after a 40-week gestation. The pregnancy was initially supervised in a private clinic from two months until eight months and thereafter in our hospital. She developed glycosuria at six months of gestation; however, the fasting blood sugar was normal (FBS 4.6 mmol/L). The mother was not a known diabetic and had no family history of diabetes. Her first delivery was a male weighing 4.2 kg at birth. There was no gestational diabetes in that pregnancy. There was a positive history of big babies in the mother’s family. Her younger sister delivered a third child who weighed 5.2 kg.
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Posted by James
INTRODUCTION
Renal vein thrombosis (RVT) is a multifactorial disease that predominantly affects newborn infants. It may follow maternal diabetes, asphyxia, hypertonic dehydration, congenital heart disease, acute blood loss, shock, presence of an indwelling umbilical venous catheter and sepsis. A review of the literature showed that RVT of the newborn might be of unknown etiology and probably occurs before birth. Genetic mutations, such as factor V Leiden, is a risk factor especially for in utero RVT. Other risk factors include prolonged central venous cannulation, hereditary thrombophilia, trauma, burns, and Wilms tumor. In the adult and children it is often a silent complication of the nephrotic syndrome, the hypercoagulability of which may be an important factor in the pathogenesis of the thrombosis.
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